Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines.Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.
Position Summary Under the direction of the Vice President, Radiation Sciences and Molecular Imaging, the Senior Director, Radiation Sciences and Molecular Imaging will play a key leadership role in supporting the management, mentorship, and development of the Radiation Sciences team. This individual will help guide and support junior team members, fostering collaboration and professional growth within the team. In addition to team leadership, the Senior Director will oversee key processes and work cross-functionally with divisions across Fusion, including but not limited to Clinical Operations, Preclinical Teams, Pharmacometrics, DMPK, and Regulatory Affairs. The role will also involve working with and helping manage external vendors and contractors to ensure the successful execution of ongoing and upcoming clinical trials. This position requires a strategic mindset, strong leadership, and the ability to navigate complex projects while collaborating effectively across internal and external stakeholders. Responsibilities • Optimize and review nuclear medicine imaging protocols, including quality control (QC) parameters, image acquisition and reconstruction, radiation dose determination, and protocol dose management. • Define requirements and technical support for imaging execution at clinical sites, ensuring proper implementation and adherence to study protocols. • Design and oversee quality control protocols, working with both internal teams and external partners for imaging review and processing. • Provide training, mentorship, and problem-solving support to internal and external clinical study teams to ensure study objectives are met. • Perform image-based, patient-specific dosimetry calculations (internal dosimetry, not external beam radiation therapy [EBRT]). • Help lead the Radiation Sciences team on imaging protocol optimization, ensuring alignment with best practices in QC, image acquisition, radiation dose management, and compliance with regulatory standards. • Support regulatory compliance efforts related to radioactive materials, staying current with guidelines from regulatory and professional organizations (e.g., SNMMI, NRC, and international regulatory bodies). • Contribute to research and discovery projects as needed, providing scientific and technical expertise to advance innovation in radiation sciences and molecular imaging. • Travel as needed (10-20%). Qualifications • A bachelor’s degree in physical sciences, mathematics, or a related field, followed by a PhD or Doctorate in medical physics, physics, or a related scientific discipline (required). • Medical physics residency or postdoctoral training and board certification (preferred but not required). • 10–15 years of clinical experience and 2–5 years of industry experience in relevant fields. • Experience with radiopharmaceuticals, nuclear medicine, SPECT and PET imaging techniques, image reconstruction, and camera quality control procedures (required). • Strong understanding of radiation biology and radiation physics (required). • Experience with personalized dosimetry for radiopharmaceuticals and proficiency in software such as OLINDA, MIM, and other imaging/dosimetry tools (required). • Working knowledge of at least one programming language (e.g., MATLAB, R, Python) and familiarity with DICOM, PACS, and image processing techniques. • Ability to interpret and apply imaging-related project requirements within clinical study protocols. • Strong analytical skills with advanced problem identification and problem-solving abilities, particularly in clinical and technical applications related to radiation sciences. • Knowledge of radioactive materials regulations and guidelines from professional and regulatory organizations (e.g., AAPM, SNMMI, NRC, and international regulatory bodies). Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.