Scientist, Protein Biochemistry at GSK in Rockville, MD

Scientist, Protein Biochemistry

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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccines and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccines as well as to antibodies, biologics, and small molecules.

We’re looking for a passionate and highly motivated protein biochemist to join the CoE.

As a crucial member of our team, you will be at the center of our protein expression and purification operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design and purification from bacterial, insect, and mammalian cells. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with and mentors junior colleagues within the department and across therapeutic areas. The position will require active collaboration with diverse teams to work together and address key challenges.

This role will initially be located at the GSK’s Rockville site in Maryland from 2024 to 2025, and will permanently move to Cambridge, Massachusetts afterwards.

Key Responsibilities:

Maintain insect and mammalian cell cultures, perform cell transfections for recombinant protein expression.
Contribute to the design of new constructs and mutants based on structural analysis.
Work closely with the protein production and biophysics teams to select the best constructs and conditions for structural and animal studies.
Carry out protein purification tasks as required by the project to generate structural reagents.
Perform biochemical and biophysical experiments to characterize the purified proteins.
Document your work and ensure appropriate quality control experiments are carried out to support intellectual property and reagent reuse by other groups.
Present results and progress updates at team meetings.

Basic Qualifications:

PhD degree in life sciences with 0+ years of experience in a related biotechnology field or Masters degree with at least 2 years of experience in a related biotechnology field.
Minimum of one year of hands-on experience on protein expression and purification in the research lab or biological manufacturing facility.
Minimum of one year of experience purifying protein from mammalian cell culture including HEK293 and/or CHO cell lines.
Minimum of one year of experience in the operation and maintenance of AKTA systems.
Minimum of one year of experience performing common lab techniques including liquid chromatography (SEC, ion-exchange, affinity columns), SDS-PAGE, western blot.

Preferred Qualifications:

Experience in molecular biology techniques, cloning, PCR, Gel electrophoresis.
Experience with the purification of proteins from additional protein expression systems including bacterial, insect and/or yeast.
Familiarity with buffer exchange, TFF, and related process techniques.
Ability to further characterize purified material using biophysical techniques including HPLC, nanoDSF, BLI, SPR and/or mass photometry.

Excellent problem-solving skills and the ability to troubleshoot technical issues.
Demonstrated ability to work independently and as part of a diverse team.
Demonstrated ability to manage competing priorities and stakeholders.
Strong communication skills.

Able to efficiently manage uncertainty, changes in priority and timeline restrictions.
Excellent oral and written communication skills with a fluency in English.

#Vx-Cam

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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